Resveratrol Shows Exercise Benefits

Dietary intake of the red wine polyphenol resveratrol is known to promote cardiovascular health in the general population—this is the source of the so-called French Paradox.  When it comes to the other half of the health equation—regular exercise—it appears that this extract might also provide some assistance. According to a recent animal trial, resveratrol may help boost exercise performance by improving strength, endurance and fatty acid metabolism.

For the study, two groups of male Wistar rats were randomly assigned to either a standard diet or one supplemented with resveratrol, while simultaneously undergoing a treadmill-based exercise program, conducted five days a week, for a period of 12 weeks. The exercise regimen was progressive, beginning with 10 minuts and incrementally increasing to 20 over the course of the study.

The research team found that the compound improved exercise performance, heart function and muscular strength, all in addition to promoting positive changes in dietary metabolism. Specifically, overall improvement in the resveratrol-supplemented group on exercise performance averaged 21 percent higher over the course of the study, as compared to the control group.

Researchers reported that this supplementation also improved several parameters related to cardiovascular performance. Left ventricular ejection force—meaning more powerful heart muscle contractions and increased blood flow—was observed to increase by 10 percent in the experimental group as compared to the control group. In addition, an increase in fatty acid oxidation—the optimization of fatty acid metabolism as a fuel source for exercise—displayed a noticeable, statistically significant increase.

In regard to the study, researchers had this to say: “Based on these findings, we conclude that resveratrol is an ergogenic aid that improves exercise training via changes in skeletal muscle function and cardiac performance, but also improves energy metabolism.”

As an additional clarification, they summarized the results by comparing the effects of resveratrol to actually embarking on an exercise program; in terms of observed biomarkers, the results were very similar.
“We were excitied when we saw that resveratrol showed results similar to what you would see from extensive endurance exercise training.”

The next project for this research group will involve resveratrol in a human-based, therapeutic application, examining its effects on diabetics who have experienced heart failure, and for whom such endurance training, though potentially beneficial, is not feasible from a safety standpoint. The 10-week study will attempt to reinvigorate heart function in this group through resveratrol supplementation, thereby restoring an enhanced degree of health and quality of life.